Description
This animation explains a rare hemolytic disease, called Pyruvate Kinase Deficiency or PK deficiency. Our objectives are to visualize the pathophysiology, the current state of supportive care and addressing the unmet need in understanding the root cause of the disease, as well as highlighting the possible treatment for PK deficiency.
This video is a world first in depicting the full glycolytic pathway using detailed 3D animation.
Deliverables
Scientific 3D animation - US + Global Markets, High-resolution images
Client
Agios Pharma
Agios Pharma
Massachusetts, USA
What is Pyruvate Kinase Deficiency
1Pyruvate kinase deficiency is an inherited lack of the enzyme pyruvate kinase (PK), which is used by red blood cells. Without this enzyme, red blood cells break down too easily, resulting in a low level of these cells (hemolytic anemia).
2PK deficiency is passed down as an autosomal recessive trait. This means that a child must receive the non-working gene from both parents to develop the disorder.
Pyruvate kinase deficiency is found in people of all ethnic backgrounds. However, certain populations, such as the Amish, are somewhat more likely to develop the condition.
references: 1nih.gov, 2scripps.org