Pyruvate Kinase Deficiency
medical animation

mode of action animation for a biotech firm that develops novel therapeutics for rare diseases
and cancers via metabollic intervention.

Description
This animation explains a rare hemolytic disease, called Pyruvate Kinase Deficiency or PK deficiency. Our objectives are to visualize the pathophysiology, the current state of supportive care and addressing the unmet need in understanding the root cause of the disease, as well as highlighting the possible treatment for PK deficiency.

  • Client

    Agios Pharma

  • Deliverables

    Scientific 3D animation - US + Global Markets
    high-resolution images

I want to note that the video was a massive success! It was incredibly well received by both Agios employees and physician attendees. One of the "fathers" of PK deficiency, who has published the vast majority of all literature on the disease, came to see the video and was blown away, particularly by the production value and how everything was depicted.

Agios Pharma | MASSACHUSSETTS, USA


PK Deficiency

What is Pyruvate Kinase Deficiency

1Pyruvate kinase deficiency is an inherited lack of the enzyme pyruvate kinase (PK), which is used by red blood cells. Without this enzyme, red blood cells break down too easily, resulting in a low level of these cells (hemolytic anemia).

2PK deficiency is passed down as an autosomal recessive trait. This means that a child must receive the non-working gene from both parents to develop the disorder.

Pyruvate kinase deficiency is found in people of all ethnic backgrounds. However, certain populations, such as the Amish, are somewhat more likely to develop the condition.

references: 1nih.gov, 2scripps.org

Related Work

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